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Multiple sclerosis is a disease caused by autoimmune damage to the central nervous system including the brain, which affects roughly two and a half million people worldwide. Symptoms include muscle weakness and paralysis, and the disease can progress rapidly and unpredictably and may eventually lead to death.
Treatment usually includes the use of anti-inflammatory and immunosuppressive drugs which have potentially severe side effects. Animal models of Multiple sclerosis have been successfully treated using blockers of the Kv1.3 Potassium Channel, which selectively inhibit the function of effector memory T cells. |
