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Kv1.3 Potassium Channel

Kv1.3 Potassium Channel: A voltage-gated, delayed-rectifier potassium ion channel that regulates membrane potential and calcium signaling in human effector memory T cells. Kv1.3 is a member of a large family of mammalian potassium channels, and the functional channel in human T lymphocytes is composed of four identical Kv1.3 sub units. Specific blockers of the Kv1.3 channel are being developed as therapeutics for diverse autoimmune diseases.

These blockers are effective in six animal models of autoimmune diseases: multiple sclerosis, type-1 diabetes mellitus, rheumatoid arthritis, allergic contact dermatitis, bone resorption due to periodontitis and delayed type hypersensitivity, and they have excellent safety profiles.

 
 
February 2011
February 2011 AIRMID partners with Circassia to develop topical PAP-1
January 2010
Joe Sum joins AIRMID Board of Directors
July 2009
AIRMID partners with Kineta
to develop ShK peptides

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