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Effector memory T cells

Effector Memory T cells: A highly mature population of immune T-cells shown to be responsible for the tissue damage which characterizes many autoimmune diseases. Effector memory T cells (TEM) were originally defined by their expression of cell surface markers (CD3+, CCR7-, CD45RA-), and can enter sites of inflammation in non-lymphoid tissues, while not participating in the process of lymphoid recirculation carried out by most other lymphocytes. TEMs have been shown to uniquely express high numbers of the Kv1.3 potassium channel and depend on these channels for their function.

Suppressing the function of these cells by selectively blocking the Kv1.3 channel offers the potential for highly effective therapy of autoimmune diseases with minimal effects on either beneficial immune responses or other organs.

 
 
October 2016
October 2016 Press Release on KPI Therapeutics Presenting Positive Data at Skin Disease Conference
June 2016
June 2016 Press Release About Promising Results of Dalazatide in Lupus Study
June 2016 Fact Sheet: What Is Lupus?
January 2016
January 2016 Press Release on KPI Biotech Showcase
January 2016 Board Member George Miljanich passes
December 2015
December 2015 AIRMID Makes Board Changes
November 2015
November 2015 New Lupus Treatment Being Tested for Younger Patients

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